In this issue of Neuroimaging Clinics, guest editors Drs. Natalia Nagornaya and Gaurav Saigal bring their considerable expertise to the topic of Imaging of Acute Encephalopathies. Top experts discuss hypoxic ischemic encephalopathy; stroke-like syndromes in encephalopathy; metabolic derangement and vitamin deficiencies in encephalopathy; vascular and hematologic disorders; autoimmune, paraneoplastic, or idiopathic disorders in encephalopathy; and more.